Recent selected papers

This is a selection of the most relevant recent papers. You can access the full list here

  1. Macias, M.J.*; Martin-Malpartida, P. and Massagué J.* (review). Structural determinants of Smad function in TGF-beta signaling. TiBS, 40(6), 296-308, 2015.
  2. Beich-Frandsen M, Aragón E, Llimargas M, Benach J, Riera A, Pous J, Macias M.J.* Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2 fold. Acta Crystallogr D Biol. 2015.
  3. (Martin-Malpartida P., Batet M., Kaczmarska Z.), Freier R., Gomes T., Aragón E., Zou Y., Wang Q., Xi Q., Ruiz L., Vea A., Márquez J.A., Massagué J.,* and Macias M.J.* Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat. Commun. 8(1), 2070, 2017.
  4. Guca E., Suñol D., Ruiz L., Konkol A., Cordero J., Torner C., Aragon E., Martin-Malpartida P., Riera A., Macias M.J.* TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling. NAR 46(17), 9220- 9235, 2018.
  5. (Aragón E., Wang Q., Zou Y.), Morgani S.M., Ruiz L., Kaczmarska Z., Su J., Torner C., Tian L., Hu J., Shu W., Agrawal S., Gomes T., Márquez J.A., Hadjantonakis A.K., Macias M.J.* and Massagué J.* Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling. Genes & Development, 2019
  6. (Ruiz L., Kaczmarska Z., Gomes T.), Aragon E., Torner C., Freier R., Baginski B., Martin-Malpartida P., de Martin Garrido N., Marquez J.A., Cordeiro T., Pluta R., Macias M.J.* Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes (under review, 2019) 10.1101/833319 on bioRxiv
  7. Maisuradze G.G., Medina J., Kachlishvili K., Krupa P., Mozolewska M.A., Martin-Malpartida P., Maisuradze L., Macias M.J.* and Scheraga H.A. * Preventing fibril formation of a protein by selective mutation. Proc. Natl. Acad. Sci. USA, 112(44): 13549-54, 2015.
  8. Schelhorn C., Martín-Malpartida P., Suñol D., and Macias M.J.* Structural Analysis of the Pin1-CPEB1 interaction and its potential role in CPEB1 degradation. Scientific Reports, 5, 14990, 2015.
  9. Martín-Gago P., Rol Á., Todorovski T., Aragón E., Martin-Malpartida P., Verdaguer X., Vallès Miret M., Fernández- Carneado J., Ponsati B., Macias M.J.*, Riera A. Peptide aromatic interactions modulated by fluorinated residues: Synthesis, structure and biological activity of Somatostatin analogs containing 3-(3',5'-difluorophenyl)-alanine., Scientific Reports, 6, 27285, 2016
  10. Rol Á., Todorovski T., Martin-Malpartida P., Escolà A., Gonzáles-Rey E., Aragón E., Verdaguer X., Vallès-Miret M., Farrera-Sinfreu J., Puig E., Fernández-Carneado J., Ponsati B., Delgado M., Riera A., Macias M.J.* Structure- based design of a Cortistatin analog with improved immunoregulatory activity against inflammatory bowel disease (@bioRxiv,, manuscript under revision).